Neuroprotective Mechanisms of Methylene Blue
نویسندگان
چکیده
منابع مشابه
Neuroprotective Actions of Methylene Blue and Its Derivatives
Methylene blue (MB), the first lead chemical structure of phenothiazine and other derivatives, is commonly used in diagnostic procedures and as a treatment for methemoglobinemia. We have previously demonstrated that MB could function as an alternative mitochondrial electron transfer carrier, enhance cellular oxygen consumption, and provide protection in vitro and in rodent models of Parkinson's...
متن کاملMethylene blue is neuroprotective against mild traumatic brain injury.
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Methylene blue (MB) has known energy-enhancing and antioxidant properties. This study tested the hypothesis that MB treatment reduces lesion volume and behavioral deficits in a rat model of mild TBI. In a randomized double-blinded design, animals received either MB (n=5) or vehicle (n=6) after TBI. Studies were p...
متن کاملBinding Mechanisms of Methylene Blue and Hoechst 33258 with Dna
In this work the data of methylene blue (MB) and Hoechst 33258 interaction with DNA are presented. It has been shown that at 0.002 M ionic strength of solution MB is bound to double-stranded DNA by three modes: intercalation, semi-intercalation and electrostatic. It was revealed that at higher ionic strengths of solution complete intercalation of MB becomes thermodynamically unacceptable. It wa...
متن کاملMethylene blue for MDI.
Bryer JB, Borrelli D J, Matthews EJ Jr, Kornetsky C (1983): The psychological correlates of the DST in depressed patients. Psychopharmacol Bull 19:633-637. Carroll B, Feinberg M, Greden J, et al (1981): A specific laboratory test for the diagnosis of melancholia. Arch Gen Psychiatry 38:15-22. Nelson WH, Khan A, Orr WW Jr, Tamragouri RN (1984): The dexamethasone suppression test: Interaction of ...
متن کاملNeuroprotective Efficacy of Methylene Blue in Ischemic Stroke: An MRI Study
Methylene blue (MB) has unique energy-enhancing and antioxidant properties and is FDA-approved drug to treat methemoglobinemia and cyanide poisoning. This study evaluated the efficacy of MB to treat ischemic stroke in rats using longitudinal MRI and behavioral measures. Rats were subjected to 60-minute middle-cerebral-artery occlusion. In a randomized double-blinded design, vehicle or MB was ad...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.691.9